StackWave Affinity™

Analysis

StackWave Affinity's Analysis module offers a range of tools and techniques for drug discovery analysis. Bioinformatics tools provide sequence analysis and alignment, titration and dose response tools aid in determining optimal therapeutic dosage, and built-in NGS tools support identification and analysis of the most interesting clones out of discovery campaigns.

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StackWave Affinity™ Analysis Module

Identify the best therapeutic candidates with powerful analysis tools

StackWave Affinity's Analysis module offers a range of techniques for comprehensive analysis of lead discovery candidates. With its protein characterization tools, scientists can delve into a protein's properties to better understand its behaviors. This enables researchers to more quickly identify the best therapeutics, minimize unwanted effects, and evaluate the effects of lead optimization efforts.

Additionally, the module provides support for common analyses such as titration and dose response. Through our titration tools, scientists can back-calculate the concentration of antibody from the standard curve for pharmacokinetics. This aids in determining the optimal therapeutic dosage, striking a balance between achieving desired effects and minimizing side effects. Furthermore, our NGS tools streamline NGS analysis on sequence databases and guide users in identifying clones of interest based on enrichment, mutation frequency, and amino acid properties.

Click here to download the StackWave Affinity LIMS presentation

Image of plasmid circular map with restriction sites
Image of antibody sequence regions
Image of clone lead identification plot
Image of sequence alignment for antibody region
Image of operational antibody project data
Affinity in Action

Manage your entire process, from discovery to lead characterization

With Affinity, it's never been easier to collaborate effectively on drug discovery and development. Spend more of your time on discovery instead of data entry by using one solution that provides all of the tools you'll need. Request a demo or free trial today.

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Collaborate

Facilitate collaboration between discovery, production, and analytics teams

Integrate

Fully integrated, from target identification to lead characterization

Consolidate

Single source of truth for all assay data

Analyze

In-depth analysis of lead antibodies

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Learn more about our solutions for Antibody Discovery

  • Sequence Analysis

  • Phage Panning

  • Lead Characterization

  • Hybridoma Production

Sequence Analysis

Leverage Affinity’s built-in sequence analysis tools to identify the unique antibodies in your discovery campaign results without having to license or build a separate bioinformatics system. Additional sequence search tools take advantage of Affinity’s sequence and variable region databases to quickly find related sequences.

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Phage Panning

Phage panning allows you to narrow the enormous diversity represented by your phage libraries to a manageable set of antibodies for further study. Create visual designs of your phage panning experiment to track which combinations of antigens and other inputs produced the most promising leads. From the pools of phage output produced, generate sets of screening plates for assaying, sequencing, screening, and analysis.

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Lead Characterization

StackWave Affinity provides workflows for phage, hybridoma, and single B-cell campaigns, assay data management, sequence analysis, custom reporting, and plate generation in a single solution. These tools integrate seamlessly to help discovery teams quickly identify their most promising lead antibodies. Automation support for liquid handling platforms and assay data ingest allows for high-throughput screening of campaign results.

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Hybridoma Production

Manage the complexity of hybridoma campaigns with an actual animal study management solution that connects seamlessly with hybridoma plate generation. Generated plates can be screened, sequenced, filtered, and lead antibodies identified using an intuitive set of tools that combine assay data management, sequence analysis, and custom reporting.

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"StackWave gives us confidence in our leads by collecting all of the data about our potential therapeutics in one place and making that data actionable by allowing us to compare antibodies of interest."

Director of R&D IT | Scholar Rock Chris Fuller

"I worked with StackWave for ~4 years at my previous job to implement our LIMS. It was a great learning experience. We put in place an incredible system for our entire workflow, from plasmid registration to in-vivo study data registration."

Senior Scientist II, Protein Sciences Nidhi Jain

"StackWave’s Platform allowed us to collaborate on our in-vivo studies in a web browser at home... I would highly recommend StackWave for therapeutic discovery teams looking to improve collaboration between teams."

Associate Director, In Vivo Pharmacology Leanne Lanieri
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One Tool for Antibody Discovery

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